Brendel grew up in Wiesbaden, where he took singing lessons with Rolff Sartorius during his time at the conservatory. In 1971, he debuted at the Pfalztheater in Kaiserslautern as Guglielmo in Così fan tutte. His artistic home for the greater part of his career was the Bayerische Staatsoper in Munich, where in 1977 he became the youngest Kammersänger in the company’s history.